Protective effects of simvastatin on atrioventricular node during simulated experimental atrial fibrillation in vitro

نویسندگان

  • ahmadali shirafkan
  • ali davariyan
  • aref salehi
  • fakhri badaghabadi
  • fatemeh alizadeh
  • mohsen nayebpour
  • mona pourabouk
  • saeid saleki
  • sorosh aminosariyeh
چکیده مقاله:

Introduction: Recent evidence has indicated that statins can reduce the incidence of both supraventricular and ventricular arrhythmias with various mechanisms. The primary goal of the present study was to determine direct protective role of simvastatin in modifying concealed conduction and the zone of concealment in a simulated model of atrial fibrillation (AF) in an isolated atrioventricular (AV) node in rabbits. Methods: Male Newsland rabbits (1.5-2 kg) were used in all experiments. Stimulating protocols (recovery, AF, zone of concealment) were used to study electrophysiological properties of the node in one group (N=8). All of the stimulated protocols were repeated in the presence and absence of different doses of simvastatin (0.5-10 μm). Results were shown as mean ± S.E. Results: Significant inhibition of the basic properties of the AV node was observed after the addition of simvastatin. Significant prolongation of Wenkebakh index (wbcl) from 138.7±5.6 to 182.1±6.9 and functional refractory period (FRP) from 157.7±5.9 to 182.1±6 msec at the concentration of 10 μM was observed. Maximum efficacy of simvastatin in atrial fibrillation (AF) protocol was observed at the concentration of 3.10 μM, that was accompanied with prolonged HH interval and increased number of concealed beats. Zone of concealment significantly increased at the concentrations of 1.3 and 10 μM. Conclusion: This study shows the protective effect of simvastatin in the prolongation of ventricular beats during atrial fibrillation. The effect of simvastatin in increasing AV-nodal refractory period and zone of concealment are probably the anti-arrhythmic mechanisms of this drug.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

protective effects of simvastatin on atrioventricular node during simulated experimental atrial fibrillation in vitro

introduction: recent evidence has indicated that statins can reduce the incidence of both supraventricular and ventricular arrhythmias with various mechanisms. the primary goal of the present study was to determine direct protective role of simvastatin in modifying concealed conduction and the zone of concealment in a simulated model of atrial fibrillation (af) in an isolated atrioventricular (...

متن کامل

Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation

Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyc...

متن کامل

Role of nitric oxide on the electrophysiological properties of isolated rabbit atrioventricular node by extracellular field potential during atrial fibrillation

Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...

متن کامل

Frequency-dependent effects of diltiazem on the atrioventricular node during experimental atrial fibrillation.

Calcium channel blockers depress atrioventricular (AV) nodal properties in vivo in a frequency-dependent manner, suggesting that selective drug action during supraventricular arrhythmias may result from use-dependent properties. The present study was designed to examine whether or not the rate-dependent actions of diltiazem account for its therapeutic effects during atrial fibrillation. The det...

متن کامل

نقش آدنوزین در اثرات محافظتی سیمواستاتین بر خواص گره دهلیزی- بطنی در مدل فیبریلاسیون دهلیزی ایجاد شده در قلب ایزوله خرگوش

Background: The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhi-bitors (statins) have revolutionized the treatment of hypercholesterolemia. Some evide-nce indicated the role of nodal refractoriness and concealed conduction in anticipating the ventricular rate during atrial fibrillation. Recent evidence has indicated that statins can reduce the incidence of both supraventricular a...

متن کامل

Effects Of Fast Pathway Ablation On The Concealment Zone And Electrophysiological Behavior Of AV-Node During Atrial Fibrillation.

Objectives: Dual pathways have a determinant role in the occurrence of atrio nodal tachyarrhythmia (AVNRT). The aim of present study is to determine the role of slow pathway (SP) in the concealment zone and protective role of AV node during atrial fibrillation (AF). Material &Methods: In 7 isolated nodal rabbit preparation zone of concealment and concealed conduction is quantified by Specif...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 14  شماره None

صفحات  127- 136

تاریخ انتشار 2010-07

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023